The Oscar-winning actress has replaced Cate Blanchett - who has apparently left the project - to play famed photographer Margaret Bourke White in the love story, reported Showbiz 411.
Barbra Streisand had also been poised to direct the film, her first in 16 years, but has decided to pass on the job due to scheduling conflicts. Producers are now on the hunt for a new director to take over.
Colin Firth remains attached to play Margaret's husband, novelist Erskine Caldwell.
Skinny And Cat, which focuses on the couple's fiery romance and creative pairing, has been in development since 1982, when producer Linda Yellen wrote her first script.
READ MORE: http://www.independent.ie/entertainment/movies/rachel-weisz-joins-skinny-and-cat-29189632.html